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US 4,999,356 AGranted
1-phenyl-3-(1-piperazinyl)-1H-indazoles
AssigneeHoechst-Roussel Pharmaceuticals Inc.
InventorJoseph T. Strupczewski
Life of this patent
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Abstract
Novel 1-phenyl-3-(1-piperazinyl)-1H-indazoles, intermediates and processes for the preparation thereof, and methods for alleviating pain, treating convulsions, and treating depression utilizing compounds or compositions thereof are disclosed.
Claims142
A compound of the formula ##STR12## wherein n is an integer having a value of 0 or 1;
- m is an integer having a value of 0 to 2 inclusive;
- X and Y are independently selected from the group consisting of halogen, loweralkyl, loweralkoxy, loweralkylthio, diloweralkylamino, loweralkylamino, amino, nitro, cyano, mercapto, hydroxy, and trifluoromethyl, wherein for each value of m, Y may be the same or different;
- and R is selected from the group consisting of hydrogen, loweralkyl, cycloalkylloweralkyl, loweralkenyl, hydroxyloweralkyl, diloweralkylaminoloweralkyl, diloweralkyphosphinylloweralkyl, cyano, loweralkoxycarbonyl, loweralkanoyl, aminocarbonyl, loweralkylaminocarbonyl, and ##STR13## wherein q is an integer having a value of 0 to 5, inclusive, X.sup.1 is selected from the group consisting of halogen, loweralkyl, loweralkoxy, loweralkylthio, diloweralkylamino, loweralkylamino, amino, nitro, cyano, mercapto, hydroxy and trifluoromethyl, and p is an integer having a value of 0 to 2inclusive, wherein for each value of p, X.sup.1 may be the same or different;
- the term cycloalkyl in each occurrence signifying a cyclic hydrocarbon radical of the formula --C.sub.x H.sub.2x-1 wherein X has a value of 3 to 7 inclusive, the geometrical isomers, optical antipodes or pharmaceutically acceptable acid addition salts thereof.
1 more element
Dependencies are inferred from the claim text.