Pasteurella multocida vaccine
AssigneeUniversity of Georgia Research Foundation, Inc.
InventorsJohn R. Glisson, Charles L. Hofacre
Life of this patent
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Abstract
Mutogenesis of the Clemson University (CU) vaccine strain of P. multocida with N-methyl-N-nitro-N-nitrosoguanidine resulted in temperature sensitive (TS) mutants which grew at 37.degree. C. but not 42.degree. C. Two mutants, PM#1 and PM#3, were found to provide turkeys with a level of protection against challenge with a virulent serotype 3 P. multocida strain (P-1059) comparable to the protection provided by the CU strain. Intravenous (IV) inoculation of PM#1, PM#3, and CU was used to determine differences in virulence. PM#1 and PM#3 resulted in lower mortality and lameness than the CU strain. Histopathological evaluation of spleens at 24, 48, and 72 hours post IV inoculation demonstrated that the CU strain induced 2 times more splenic necrosis than either PM#1 or PM#3.
Claims10
A vaccine for poultry against Pasteurella multocida comprising a mutated strain of Pasteurella multocida, PM#1, deposited with the American Type Culture Collection, Rockville, Md. on Apr. 19, 1988 and designated ATCC 53766, derived from the Clemson University strain and effective against serotype 3 Pasteurella multocida.
A vaccine for poultry against Pasteurella multocida comprising a mutated strain of Pasteurella multocida, PM#3, deposited with the American Type Culture Collection, Rockville, Md. on Apr. 19, 1988 and designated ATCC 53767, derived from the Clemson University strain and effective against serotype 3 Pasteurella multocida.
A method for immunizing poultry against infection with Pasteurella multocida comprising vaccinating the poultry with a mutated strain of Pasteurella multocida, PM#1, deposited with the American Type Culture Collection, Rockville, Md. on Apr. 19, 1988 and designated ATCC 53766, derived from the Clemson University strain and effective against serotype 3 Pasteurella multocida.
A method for immunizing poultry against infection with Pasteurella multocida comprising vaccinating the poultry with a mutated strain of Pasteurella multocida, PM#3, deposited with the American Type Culture Collection, Rockville, Md. on Apr. 19, 1988 and designated ATCC 53767, derived from the Clemson University strain and effective against serotype 3 Pasteurella multocida.
Dependencies are inferred from the claim text.