Tumor associated monocoloal antibodies derived from human B-cell line
AssigneeAkzo N.V.
InventorsMichael Hanna, Jr., Martin V. Haspel, Herbert C. Hoover, Jr.
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Abstract
Hybridoma cell lines and transformed B-cell lines are derived from B-cells of cancer patients actively immunized with autologous tumor antigens and used to produce monoclonal antibodies having specificity for tumor-associated antigens. The monoclonal antibodies can be used in both diagnostic procedures and therapy for human cancers.
Claims2
A hybridoma cell line producing human monoclonal antibodies specific for colon tumor associated antigens selected from the group consisting of LiCo6a3-1 (HB 8493), Lico 7a4 (HB 8494) and Co 28A32 (HB 9380).
A transformed human B-lymphocyte producing human monoclonal antibodies specific for colon tumor associated antigens selected from the group consisting of LiCo 16-88 (HB 8495) and Lico 16-88 (HB 8496).
Dependencies are inferred from the claim text.