Covered retard forms
AssigneeCiba-Geigy Corporation
InventorJoel Sinnreich
Life of this patent
Estimating the term…
Abstract
The invention relates to a covered, solid retard form which in the case of oral administration remains in the stomach during periodic emptying and ensures continuous release. This dosage form contains the following components: (a) at least one component that expands on contact with body fluid and that contains a physiologically active substance or a combination of such substances, (b) at least one permeable hydrophilic membrane which surrounds component (a) and which is expansible at the site of use, and optionally (c) a covering which surrounds components (a) and membrance (b) and which disintegrates without delay under the action of a body fluid at the site of use.
Claims5
A film coated or capsule dosage form which effects delayed release of an active pharmaceutical ingredient in the stomach which comprises:
- (a) at least one component that expands on contact with gastric juice and contains an agent capable of releasing carbon dioxide or nitrogen, a pharmaceutically active ingredient or a combination thereof and, optionally, a pharmaceutically acceptable hydrophilic swelling agent selected from the group consisting of lower alkyl ethers of cellulose, starches, water-soluble aliphatic or cyclic poly-N-vinylamides, polyvinyl alcohols, polyacrylates, polymethacrylates, polyethylene glycols and mixtures thereof and further pharmaceutical formulation adjuncts used for the manufacture of oral dosage forms,
- (b) at least one hydrophilic membrane in the form of a sachet which contains component (a), is expansible by inflation and floating on the aqueous phase in the stomach and permeable to gastric juice and,
- (c) a film coating or capsule form which contains components (a) and (b) and which disintegrates without delay in the stomach under the action of gastric juice.
Dependencies are inferred from the claim text.