Sustained release drug-resin complexes
AssigneeRichardson-Vicks Inc.
InventorsWilliam J. Kelleher, Anthony E. Carpanzano
Life of this patent
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Abstract
Disclosed are oral pharmaceutical preparations which comprise a pharmacologically active drug bound to small particles of an ion-exchange resin to provide a drug-resin complex having a drug content above a specified value. The drug-resin complex is subsequently coated with a water-permeable diffusion barrier coating that is insoluble in gastrointestinal fluids thereby providing a controllable sustained release of drug under conditions encountered in the gastrointestinal tract.
Claims16
An oral pharmaceutical composition in unit dosage form consisting essentially of irregularly shaped ion-exchange resin particles with an ion-exchange capacity of less than about 6 meq/gram having particle sizes ranging from about 10 to about 500 microns, said particles having a pharmacologically active drug bound thereto wherein said rug comprises more than about 38% by weight of the drug-resin complex, the ratio of pharmacologically-active drug to resin ranging from about 0.5:1 to about 1.5:1 and wherein said drug-resin complex particles have been subsequently coated with from about 1.5% to about 25% by weight of the drug-resin complex of a water-permeable diffusion barrier and wherein said composition provides controlled release of said active drug.
An oral pharmaceutical composition of unit dosage form consisting essentially of regularly shaped ion-exchange resin particles with an ion-exchange capacity of less than about 6 meq/gram having particle sizes ranging from about 10 to about 500 microns, said particles having a pharmacologically active drug bound thereto wherein said drug comprises more than about 30% by weight of the drug-resin complex, the ratio of pharmacologically-active drug to resin ranging from about 0.4:1 to about 1.5:1 and wherein said drug-resin complex particles have been subsequently coated with from about 1.5% to about 25% by weight of the drug-resin complex of a water-permeable diffusion barrier and wherein said composition provided controlled release of said active drug.
Dependencies are inferred from the claim text.