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OwnerToshiyuki Arai, Pradeep M. Gupte +1inventors
InventorsToshiyuki Arai, Pradeep M. Gupte, Sigmund E. Lasker
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A diagnostic imaging agent is provided for use in conjunction with a magnetic resonance imaging system for the imaging of spacial oxygen distribution in tissue. The imaging agent is comprised of a complex of oxygen-17, a biologically acceptable liquid carrier, such as a perfluorinated compound, and an emulsifying agent, and wherein the agent has an average particle size of less than about 0.6 microns, and an ionic composition essentially equal to that of blood. Useful information can be obtained, and in certain instances, therapy administered, by a non-envasive imaging technique relative to tissue perfusion by .sup.19 F-NMR (imaging of .sup.19 F) and oxygen utilization by .sup.1 H-NMR (imaging of H.sub.2.sup.17 O as a metabolite).
A method for the non-invasive and visual estimation of the spacial distribution of H.sub.2.sup.17 O in the tissue of a subject, said method comprising administering to said subject an effective imaging amount of a diagnostic imaging agent comprised of a complex of oxygen-17 and a biologically acceptable liquid carrier, and wherein said complex has an ionic composition essentially equal to that of blood, and an average particle size of less than about 0.6 microns, and measuring the production of H.sub.2.sup.17 O in said tissue by means of a proton magnetic resonance imaging system.
A method for the non-invasive and visual estimation of the spacial distribution of H.sub.2.sup.17 O in the tissue of a subject said method comprising administering to said subject an effective imaging amount of oxygen-17 and monitoring the in vivo production of H.sub.2.sup.17 O by means of a proton magnetic resonance imaging system.
A method for preparing a diagnostic imaging agent useful in conjunction with a magnetic resonance imaging system for the imaging of spacial oxygen distribution in the biological tissue of a subject, said agent comprised of a biologically acceptable perfluorinated compound and a biological emulsifying agent in a volume ratio of compound to emulsifying agent of at least about 4:1, and oxygen-17 in a volume ratio of compound to oxygen-17 of up to 5:1;
A method for preparing a diagnostic imaging agent for the imaging of spacial distribution of H.sub.2.sup.17 O in biological tissue, said agent comprised of a complex of oxygen-17 and a biologically acceptable liquid carrier, and wherein said complex has an ionic composition essentially equal to that of blood, and an average particle size of less than about 0.6 microns, which comprises the steps of:
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