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AssigneeBayer Aktiengesellschaft
InventorsManfred Bucheler, Hans Gehringer, Bernd Klinksiek, Bernd Koglin
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The invention relates to a process for the preparation of fine-particled, stable, pharmaceutical or cosmetic dispersions consisting of an aqueous phase and an organic phase which is insoluble or not completely soluble in water (oily phase) in which a pre-emulsion is prepared from the two phases by known emulsifying methods and in then pumped through a jet disperser, the temperature, the proportion of the aqueous and organic phases, and the pressure at the jet disperser being adjusted so that phase inversion of the emulsion is effected in the jet disperser at the same time as homogenization and fine dispersion, and in the course of which all the pressure energy is consumed in the dispersing zone and the dispersion leaves as a non-directional stream.
Process for the preparation of fine-particled, stable, pharmaceutical or cosmetic dispersions consisting of an aqueous phase and an organic oily phase which is insoluble or not completely soluble in water, characterized in that a pre-emulsion is pumped through a jet disperser which consists of one or more jets, which are designed as capillary bores with a diameter of 0.5 to 0.8 mm and have a length to diameter ratio of 1.5 to 2 the temperature, the proportions of the aqueous phase and the organic phase and the pressure at the jet disperser being adjusted so that phase inversion of the emulsion is effected in the jet disperser at the same time as homogenization and fine dispersion, and in the course of which all the pressure energy is consumed in the dispersing zone and the dispersion leaves the dispersing zone as a non-directional stream.
Dependencies are inferred from the claim text.