6- and 4-substituted-1-azabicyclo(3.2.0)heptan-3, 7-dione-2-carboxylates
AssigneeMerck & Co., Inc.
InventorBurton G. Christensen
Life of this patent
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Abstract
Disclosed are 6- and 4-substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylic acid esters and salts (I) which are useful in the preparation of 6-, 1- and 2-substituted carbapenem antibiotics. ##STR1## wherein R.sup.5 is a pharmaceutically acceptable ester moiety or a removable protecting group or an alkali or alkaline earth metal cation such as sodium or potassium and wherein R.sup.1, R.sup.2, Rhu 3 and R.sup.4 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, aryl and aralkyl. Another embodiment disclosed is a group of compounds having the formula ##STR2## where X is a leaving group.
Claims4
A compound having the structure:
- ##STR103## wherein R.sup.1 is .beta.--CH.sub.3, one of R.sup.3 and R.sup.4 is H and the other is;
- X is a leaving group;
- and Y is selected from (i) COOH or a pharmaceutically acceptable ester or salt thereof, (ii) COOR.sup.5 where R.sup.5 is a readily removable carboxyl covering group, (iii) COOM where M is an alkali metal and (iv) COO.sup.-, provided that an additional compensating cation or cationic group is present.
Dependencies are inferred from the claim text.