Method for stimulation or repair and regeneration of intestinal gut cells in infants and enhancing the immune response of t-cells
AssigneeUnion Industrial y Agro-Ganadera, S.A. (UNIASA)
InventorsAngel H. Gil, Daniel V. Morales, Eduardo R. Valverde
Life of this patent
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Abstract
Nucleosides and/or nucleotides are added to infant formula, both milk and non-milk based, to provide a formula having enhanced physiological properties and also closely resemble human milk. Additionally, nutritionally balanced diet formulations are described having nucleosides and/or nucleotides incorporated therein.
Claims16
A method for the stimulation or repair and regeneration of intestinal gut cells in infants which comprises administering to an infant in need of such stimulation an amount effective for said stimulation of an infant formula free of cow's milk, said infant formula comprising a therapeutically effective amount of carbohydrates, a source of amino acids, vegetable oils, minerals, vitamins, and at least one member selected from the group consisting of uridine, uridine phosphate and mixtures thereof;
- guanosine, guanosine phosphate and mixtures thereof;
- adenosine, adenosine phosphate and mixtures thereof;
- cytidine, cytidine phosphate and mixtures thereof and inosine, inosine phosphate and mixtures thereof.
A method for the stimulation or repair and regeneration of intestinal gut cells in infants which comprises administering to an infant in need of such stimulation an amount effective for said stimulation of an infant formula in liquid form which comprises a therapeutically effective amount of a source of amino nitrogen, carbohydrates, edible fats, minerals, vitamins and a nucleoside and/or nucleotide composition comprising at least one member selected from the group consisting of:
- (a) uridine, uridine phosphate and a mixture thereof;
- (b) guanosine, guanosine phosphate and a mixture thereof;
- (c) adenosine, adenosine phosphate and a mixture thereof;
- (d) cytidine, cytidine phosphate and a mixture thereof;
- and
- (e) inosine, inosine phosphate and a mixture thereof;
- wherein the total amount combined nucleoside and nucleotide content is in the range of between about 10 to 250 mg for each 100 g of said formula.
A method for enhancing the immune response of T-cells and for providing specific fatty acid phospholipids profiles in red blood cell membranes of infants, which comprises administering to an infant in need of enhanced immune response of T-cells an effective amount for enhancing said response of an infant formula free of cow's milk, said infant formula comprising a therapeutically effective amount of carbohydrates, a source of amino acids, vegetable oils, minerals, vitamins and at least one member selected from the group consisting of uridine, uridine phosphate and mixtures thereof;
- guanosine, guanosine phosphate and mixtures thereof;
- adenosine, adenosine phosphate and mixtures thereof;
- cytidine, cytidine phosphate and mixtures thereof and inosine, inosine phosphate and mixtures thereof.
A method for enhancing the immune response of T-cells and for providing specific fatty acid phospholipids profiles in red blood cell membranes of infants, which comprises administering to an infant in need of enhanced immune response of T-cells an effective amount for enhancing said responses an infant formula in liquid form which comprises a therapeutically effective amount of a source of amino nitrogen, carbohydrates, edible fats, minerals, vitamins and a nucleoside and/or nucleotide composition comprising at least one member selected from the group consisting of:
- (a) uridine, uridine phosphate and a mixture thereof;
- (b) guanosine, guanosine phosphate and a mixture thereof;
- (c) adenosine, adenosine phosphate and a mixture thereof;
- (d) cytidine, cytidine phosphate and a mixture thereof;
- and
- (e) inosine, inosine phosphate and mixture thereof;
- wherein the total combined nucleoside and nucleotide content is in the range of between about 10 to 250 mg for each 100 g of said formula.
A method for the stimulation or repair and regeneration of intestinal gut cells in humans which comprises administering in need of such stimulation an amount effective for said stimulation of a formula free of cow's milk, said formula comprising a therapeutically effective amount of carbohydrates, a source of amino acids, vegetable oils, minerals, vitamins, and at least one member selected from the group consisting of uridine phosphate and mixtures thereof;
- guanosine, guanosine phosphate and mixtures thereof;
- adenosine, adenosine phosphate and mixtures thereof;
- cytidine, cytidine phosphate and mixtures thereof and inosine, inosine phosphate and mixtures thereof.
A method for the stimulation or repair and regeneration of intestinal gut cells in humans which comprises administering to a human in need of such stimulation an amount effective for said stimulation of a formula in liquid form which comprises a therapeutically effective amount of a source of amino nitrogen, carbohydrates, edible fats, minerals, vitamins and a nucleoside and/or nucleotide composition comprising at least one member selected from the group consisting of:
- (a) uridine, uridine phosphate and a mixture thereof;
- (b) guanosine, guanosine phosphate and a mixture thereof;
- (c) adenosine, adenosine phosphate and a mixture thereof;
- (d) cytidine, cytidine phosphate and a mixture thereof;
- and
- (e) inosine, inosine phosphate and a mixture thereof;
- wherein the total combined nucleoside and nucleotide content is in the range of between about 10 to 250 mg for each 100 g of said formula.
A method for enhancing the immune response of T-cells and for providing specific fatty acid phospholipids profiles in red blood cell membranes of humans, which comprises administering to a human in need of enhanced immune response of T-cells an effective amount for enhancing said response of a formula free of cow's milk, said formula comprising a therapeutically effective amount of carbohydrates, a source of amino acids, vegetable oils, minerals, vitamins and at least one member selected from the group consisting of uridine, uridine phosphate and mixtures thereof;
- guanosine, guanosine phosphate and mixtures thereof;
- adenosine, adenosine phosphate and mixtures thereof;
- cytidine, cytidine phosphate and mixtures thereof and inosine, inosine phosphate and mixtures thereof.
A method for enhancing the immune response of T-cells and for providing specific fatty acid phospholipids profiles in red blood cell membranes of humans, which comprises administering to a human in need of enhanced immune response of T-cells an effective amount for enhancing said response of a formula in liquid form which comprises a therapeutically effective amount of a source of amino nitrogen, carbohydrates, edible fats, minerals, vitamins and a nucleoside and/or nucleotide composition comprising at least one member selected from the group consisting of:
- (a) uridine, uridine phosphate and a mixture thereof;
- (b) guanosine, guanosine phosphate and a mixture thereof;
- (c) adenosine, adenosine phosphate and a mixture thereof;
- (d) cytidine, cytidine phosphate and a mixture thereof;
- and
- (e) inosine, inosine phosphate and a mixture thereof;
- wherein the total combined nucleoside and nucleotide content is in the range of between about 10 to 250 mg for each 100 g of said formula.
Dependencies are inferred from the claim text.