Back to results
US 4,994,267 AGranted
Transdermal acrylic multipolymer drug delivery system
AssigneeNoven Pharmaceuticals, Inc.
InventorSteven Sablotsky
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeNoven Pharmaceuticals, Inc.
InventorSteven Sablotsky
Estimating the term…
A dermal composition comprising a drug, a multipolymer of ethylene-vinyl acetate, an acrylic polymer, and optionally one or more monomers, a natural or synthetic rubber and a tackifying agent. The ratio of the multipolymer to the rubber is, respectively, about 1:1 to about 10:1 and more preferably, 1:1 to 5:1 and more preferably 3:1. The dermal composition can optionally contain a crosslinking agent, tackifiers, penetration enhancers and other ingredients known for use in adhesives for the transdermal delivery of drugs. The dermal compositions can be produced by a variety of methods known in the preparation of drug containing adhesive preparations including the homogenous mixing of the multipolymer, drug and optional crosslinking agent and additional ingredients in solution or suspension or emulsion followed by removal of excess solvent.
An adhesive dermal composition comprising a drug, a multipolymer containing vinyl acetate/ethylene polymer and an acrylic polymer, a natural or synthetic rubber, and a tackifying agent in which the ratio by weight of the multipolymer to the rubber is about 1:10 to about 30:1 and the ratio by weight of the vinyl acetate/ethylene polymer to the acrylic polymer is about 20:1 to about 1:20.
A dermal composition comprising a steroid, a multipolymer of an acrylic polymer and a vinyl acetate/ethylene copolymer, a natural or synthetic rubber, and a tackifying agent in which the multipolymer and rubber are in a ratio, respectively, of from about 1:1 to about 20:1.
The dermal composition which comprises, as percent by weight, about 2% to about 10% ethylene/vinyl acetate copolymer, about 2% to about 20% natural or synthetic rubber, about 20% to about 60% of a polyacrylate about 5% to about 30% of a tackifying agent, and about 1% to about 50% of drug.
Dependencies are inferred from the claim text.