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US 4,992,436 AGranted
Spiro-azabicyclic muscarinic agonists
AssigneeMerck Sharp & Dohme Corp.
InventorsRaymond Baker, Leslie J. Street, John Saunders
Life of this patent
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Abstract
The present invention provides a spiro-azabicyclic compound or a salt or prodrug thereof, said compound comprising a saturated or unsaturated 5-membered heterocyclic ring containing two heteroatoms selected from oxygen, nitrogen and sulphur, no more than one of said heteroatoms being nitrogen; said heterocyclic ring having a spiro attachment to an optionally substituted azabicyclo[2.2.1]heptane or azabicyclo[3.2.1]octane ring system; which compounds are useful for the treatment of neurological and mental disorders.
Claims6
A compound of Formula II:
- ##STR29## wherein --T.sup.1 -- represents a group of formula ##STR30## in which A and B independently represent oxygen or sulphur;
- R.sup.1 and R.sup.2 independently represent hydrogen, straight-chained or branched C.sub.2-4 alkyl or C.sub.3-6 cycloalkyl and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.