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US 4,986,979 AGranted
Imaging tissue sites of inflammation
AssigneeNeoRx Corporation
InventorsA. Charles Morgan, Jr., David C. Anderson
Life of this patent
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Abstract
The present invention involves method of enhancing the amount of label accumulating at tissue sites of inflammation. Methods of the present invention take advantage of the up-regulation of surface antigenic markers on leukocytes upon activation thereof. A method of imaging utilizing a chemotactic peptide containing an affinity label and a radionuclide label conjugated to leukocytes is taught. Imaging applications of such enhancement are described.
Claims7
A method of imaging a tissue site of inflammation comprising:
- (1) withdrawing leukocytes from a patient;
- (2) constructing a chemotactic peptide or a fragment, a derivative or analog thereof containing an affinity label and a radionuclide label;
- (3) incubating leukocytes of step (1) with the peptide of step (2) for a time sufficient to permit binding thereof;
- (4) photoactivating said affinity label;
- (5) infusing into the patient an effective amount of the labeled peptide and leukocytes resulting from step (4);
- and
- (6) imaging said tissue site,
- whereby medical conditions involving tissue inflammation may be detected, evaluated and monitored.
5 more elements
Dependencies are inferred from the claim text.