Preparation of cyclopropanecarboxylic acids
AssigneeBayer Aktiengesellschaft
InventorsHeinz Hildebrand, Werner Zitzmann, Dieter Arlt, Heinz Kolbl
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Abstract
A process for the preparation of a (.+-.)-trans-cyclopropanecarboxylic acid salt thereof of the formula ##STR1## in which R is halogen or C.sub.1 -C.sub.4 -alkyl, and R.sup.1 is hydrogen or the equivalent of a metal ion, which comprises contacting a (.+-.)-trans-cyclo-propane-carboxylic ester of the formula ##STR2## in which R.sup.2 is methyl or ethyl, with a hydrolase which is of microbial origin and isolating the resulting (.+-.)-trans-cyclopropanecarboxylic acid.
Claims11
A process for the preparation of a (+)-trans-cyclopropanecarboxylic acid salt of the formula ##STR8## in which R is halogen or C.sub.1 -C.sub.4 -alkyl, and
- R.sup.1 is hydrogen or one equivalent of a metal ion, which comprises contacting a (.+-.)-trans-cyclo-propanecarboxylic ester of the formula ##STR9## in which R.sup.2 is methyl or ethyl,
- with an esterase which is of microbial origin for a time and under conditions to effect hydrolysis, and isolating the resulting (+)-trans-cyclopropanecarboxylic acid.
A biologically pure culture of microorganism Paecilomyces lilacinus (DSM 2934) or Aspergillus ustus (DSM 2935).
Dependencies are inferred from the claim text.