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AssigneeThe Trustees of Columbia University in the City of New York
InventorsDavid J. Julius, Richard Axel, Thomas M. Jessell
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The invention relates to DNA encoding a functional serotonin 5HT1c receptor, e.g., cDNA, and to the isolated, functional serotonin 5HT1c receptor encoded by such DNA. The invention also relates to mammalian cells expressing the cDNA encoding the 5HT1c receptor and to a DNA probe useful for detecting nucleic acid encoding the serotonin 5HT1c receptor. This invention provides methods for determining binding to the serotonin 5HT1c receptor, methods of detecting the expression, and the presence of the serotonin 5HT1c receptor on the surface of a cell and to a method of screening drugs to identify drugs which specifically interact with, and bind to the serotonin 5HT1c receptor on the surface of a cell.
An isolated DNA molecule encoding a serotonin 5HT1C receptor.
The transfected NIH3T3 cell designated SR3T3 and deposited under ATCC Accession No. CRL 9651.
A DNA probe useful for detecting nucleic acid encoding the serotonin 5HT1c receptor comprising a nucleic acid molecule of at least about 13 nucleotides having a sequence complementary to a sequence included within the sequence shown in FIG. 1.
Dependencies are inferred from the claim text.