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US 4,980,283 AGranted
Renin-inhibitory pepstatin phenyl derivatives
AssigneeMerck & Co., Inc.
InventorsLeeyuan Huang, Joseph Dunn, Jr., Lawrence Koupal, Jerrold Liesch, Otto Hensens, H. Boyd Woodruff
Life of this patent
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Abstract
A phenyl derivative of pepstatin A, which is much more potent than pepstatin in inhibiting renin enzyme activity and has significantly greater selectivity for renin over pepsin inhibition than does pepstatin, which is useful in treating hypertension and congestive heart failure.
Claims4
A biologically-pure culture of the strain of the organism, Streptomyces hygroscopicus, American Type Culture Collection deposit ATCC 53628, capable of producing a compound of the formula:
- ##STR4##
Dependencies are inferred from the claim text.