Cytophaga-derived immunopotentiator
AssigneeThe Regents of the University of California
InventorsRobert Mishell, William Usinger
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Abstract
Substantially pigment-free gliding bacteria adjuvant (GBA) is isolated from medium in which Cytophaga strain GB-2 has been cultured by extraction with acetone to remove pigment, enzymatic digestion and filtration to remove residual protein and nucleic acids, and affinity chromatography to remove residual lipopolysaccharide. This pure form of GBA shows unexpectedly high specific immunopotentiating activity relative to crude GBA.
Claims8
Substantially pigment-free gliding bacteria adjuvant (GBA) of Cytophaga species GB-2 (ATCC Accession No. 53485), the GBA being an exopolymer polysaccharide having a spectral absorption at 455 nm of less than 0.05 in a 1% aqueous solution and containing less than about 0.5% by weight protein and less than about 0.1% by weight lipopolysaccharide.
Dependencies are inferred from the claim text.