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US 4,977,189 AGranted
Substituted guanidinedicarbonyl derivatives
AssigneeAmerican Cyanamid Company
InventorsAndrew S. Tomcufcik, James S. Dixon, Joseph W. Epstein, Gary H. Birnberg, William J. Fanshawe
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Abstract
This disclosure describes novel substituted guanidinedicarbonyl derivatives which possess anxiolytic activity and are also useful as agents for the treatment of cognitive and related neural behavioral problems in mammals.
Claims17
A compound of the formula:
- ##STR191## wherein R.sub.1 is alkyl (C.sub.1 -C.sub.10), biphenylyl, phenyl-alkyl(C.sub.1 -C.sub.3), phenoxyalkyl (C.sub.1 -C.sub.3), naphthyl, cinnamenyl, adamantyl, cycloalkenyl (C.sub.5 -C.sub.7) or a moiety of the formula:
- ##STR192## wherein R.sub.5 is hydrogen, halogen trifluoromethyl, nitro, alkyl (C.sub.1 -C.sub.6) or alkoxy (C.sub.1 -C.sub.3);
- R.sub.2 is dialkyl(C.sub.1 -C.sub.3)-aminoalkyl(C.sub.1 -C.sub.3) or a moiety of the formulae:
- ##STR193## wherein R.sub.6 is carbamoyl, sulfamoyl, alkyl(C.sub.1 -C.sub.9)aminocarbonyl or dialkyl(C.sub.1 -C.sub.3)aminocarbonyl and R.sub.7 is carbamoyl or sulfamoyl;
- R.sub.3 is hydrogen or alkyl(C.sub.1 -C.sub.6);
- and R.sub.4 is hydrogen, halogen, trifluromethyl, nitro, alkyl(C.sub.1 -C.sub.6) or alkoxy(C.sub.1 -C.sub.6) or alkoxy(C.sub.1 -C.sub.3).
3 more elements
Dependencies are inferred from the claim text.