Peptide fragments containing HP and LP cross-links
AssigneeWashington Research Foundation
InventorDavid R. Eyre
Life of this patent
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Abstract
A method for assaying bone resorption rates by quantitating the concentration of peptide fragments derived from bone collagen, found in a body fluid. The method includes immunometric assay, fluorometric assay and electrochemical titration. The structure of specific peptide fragments having 3-hydroxypyridinium cross-links found in urine of Paget's disease patients and procedures for making monoclonal antibodies is also described.
Claims1
A purified peptide fragment consisting essentially of the amino acid sequence ##STR5## is hydroxylsyl pyridinoline or lysyl pyridinoline, and Gln is glutamine or wholly cyclized pyrrolidone carboxylic acid.
Dependencies are inferred from the claim text.