Developer for fecal occult blood tests
AssigneeLitmus Concepts, Inc.
InventorPaul J. Lawrence
Life of this patent
Estimating the term…
Abstract
Fecal occult blood tests of enhanced sensitivity, specificity, and readability are provided by employing (1) a developer or complete reagent solution that uses as a solvent system a solvent comprising at least about 50% by volume of a solvent for iron protoporphyrins such as dimethyl sulfoxide and/or (2) a multi-chromagen comprised of a mixture of guaiac and ABTS. Test results may be further improved by incorporating hemoprotein solubilizing agents, plant peroxidase inhibitors, iron/copper chelating agents, accelerators and buffers in the developer/reagent.
Claims13
A fecal occult blood test developer composition for use in a fecal occult blood test using a leuco dye indicator, comprising a solution of a hydroperoxide in an iron protoporphyrin solvent which comprises pyridine, wherein the pH of the solution is in the range of about 6.5 to about 7.5.
A fecal occult blood test developer composition for use in a fecal occult blood test using a leuco dye indicator, comprising a solution of a hydroperoxide in an iron protoporphyrin solvent which comprises ethanolamine and a co-solvent selected from the group consisting of glycerol, methyl ethyl ketone, tetramethylene sulfone, butyrolactone, tetrahydrofurfuryl alcohol, 2-methoxy ethanol and tetramethyl urea, wherein the pH of the solution is in the range of about 6.5 to about 7.5.
A fecal occult blood test developer composition for use in a fecal occult blood test using a leuco dye indicator, comprising a solution of a hydroperoxide in an iron protoporphyrin solvent which comprises 2-(diethylamino)ethylamine and a co-solvent selected from the group consisting of methyl ethyl ketone, acetonitrile, tetramethylene sulfone, tetramethyl urea, butyrolactone, tetrahydrofurfuryl alcohol, 2-methoxy ethanol, and methanol, wherein the pH of the solution is in the range of about 6.5 to about 7.5.
A fecal occult blood test developer composition for use in a fecal occult blood test using a leuco dye indicator, comprising a solution of a hydroperoxide in an iron protoporphyrin solvent which comprises diethanolamine and a co-solvent selected from the group consisting of methyl ethyl ketone, acetonitrile, tetramethylene sulfone, butyrolactone, and tetrahydrofurfuryl alcohol, wherein the pH of the solution is in the range of about 6.5 to about 7.5.
Dependencies are inferred from the claim text.