Slow-releasing granules and long acting mixed granules comprising the same
AssigneeTeysan Pharmaceuticals Co., Ltd.
InventorsYasuhisa Kitanishi, Hiroaki Taniguchi, Tsuyoshi Kochi
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Abstract
Slow-releasing granules which are characterized by coating the quick-releasing granules which comprise an active ingredient, polyvinyl pyrrolidone polymer and a disintegrator where the polymer distributes in high concentration on the surface area of the granules, with a polyacid enteric material to form a complex between the polyvinyl pyrrolidone polymer and the polyacid, and long lasting mixed granules which comprise the quick-releasing granules and the slow-releasing granules, thus showing increased bioavailability of the active ingredient and high stability sustained for a long period of time.
Claims10
Enteric granules which are characterized by comprising gastric granules which comprise, as essential components, an active ingredient, polyvinyl pyrrolidone polymer and a disintegrator, and which have a surface area where said polyvinyl pyrrolidone polymer is distributed in high concentration, wherein the gastric granules are coated with a polymeric enteric material selected from the group consisting of polymers of methacrylic acid, cellulose and vinylmethylether-maleic anhydride copolymers to form a complex between the polyvinyl pyrrolidone polymer and the polymeric enteric material on said surface area.
Mixed granules which are characterized by comprising
- (a) gastric granules which comprise, as essential components, an active ingredient, polyvinyl pyrrolidone polymer and a disintegrator, which have a surface area wherein said polyvinyl pyrrolidone polymer is distributed in high concentration, and
- (b) enteric granules which have been prepared by coating a surface of said gastric granules with a polymeric enteric material selected from the group consisting of polymers of methacrylic acid, cellulose and vinylmethylether-maleic anhydride copolymers to form a complex between the polyvinyl pyrrolidone polymer and the polymeric enteric material on the surface area.
Dependencies are inferred from the claim text.