Biodegradable matrix and methods for producing same

A biodegradable, porous, collagen-based sponge-like composition, especially useful for the treatment of skin wounds, which comprises a biodegradable, three dimensional matrix of carbodiimide and dehydrothermal cross-linked collagen fibers, wherein the fibers define randomly distributed surface and interior pores which are connected by channels within the interior of the sponge, and the channels connect the surface of the composition with the interior of the sponge-like composition, which collagen-based sponge-like composition promotes the healing of wounds by fibroblast movement into the channels and pores, attachment of the collagent inside the channels and new tissue formation in the wound, and wherein the matrix is cross-linked by a succinimidyl bifunctional ester/carbodiimide or a cyanamide, the matrix includes a fibrillar structure including a connective tissue factor selected from the group consisting of hyaluronic acid and fibronectin, and the pore size is in the range of about 100.+-.50 um.

A biodegradable porous collagen-based sponge-like structure especially useful for the treatment of skin wounds, which comprises a biodegradable collagen fiber network containing hyaluronic acid, fibronectin, or both, wherein the fibers define randomly distributed surface and interior pores which are connected by channels within the interior of the sponge, and the channels connect the surface of the composition with the interior of the sponge-like composition, the average pore size being from about 50 to about 250 um, which collagenbased sponge-like composition promotes the healing of wounds by fibroblast movement into the channels and pores, attachment of the collagen inside the channels and new tissue formation in the wound.

A biodegradable, porous, collagen-based sponge-like composition, especially useful for the treatment of skin wounds, which comprises a biodegradable, three-dimensional matrix of dehydrothermal cross-linked collagen fibers, wherein the fibers define randomly distributed surface and interior pores which are connected by channels within the interior sponge, and the channels connect the surface of the composition with the interior of the sponge-like composition, the average pore size being from about 50 to about 250 um, which collagen-based sponge-like composition promotes the healing of wounds by fibroblast movement into the channels and pores, attachment of the collagen inside the channels and new tissue formation in the wound.

A biodegradable, porous, collagen-based sponge-like composition, especially useful for the treatment of skin wounds, which comprises a biodegradable, three-dimensional matrix of carbodiimide cross-linked collagen fibers, wherein the fibers define randomly distributed surface and interior pores which are connected by channels within the interior of the sponge, and the channels connect the surface of the composition with the interior of the sponge-like composition, the average pore size being from about 50 to about 250 um, which collagen-based sponge-like composition promotes the healing of wounds by fibroblast movement into the channels and pores, attachment of the collagen inside the channels and new tissue formation in the wound.

A biodegradable, porous, collagen-based sponge-like composition, especially useful for the treatment of skin wounds, which comprises a biodegradable, three-dimensional matrix of bifunctional succinimidyl active ester cross-linked collagenfibers, wherein the fibers define randomly distributed surface and interior pores which are connected by channels within the interior sponge, and the channels connect the surface of the composition with the interior of the sponge-like composition, the average pore size being from about 50 to about 250 um, which collagen-based sponge-like composition promotes the healing of wounds by fibroblast movement into the channels and pores, attachment of the collagen inside the channels and new tissue formation in the wound.