Protective monoclonal antibody compositions for infections due to group B streptococcus
AssigneeGenetic Systems Corporation
InventorHoward V. Raff
Life of this patent
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Abstract
Immortalized cell lines have been produced that secrete human monoclonal antibodies capable of binding to bacterial species which are a major cause of neonatal sepsis and meningitis. These antibodies have been found to be protective against lethal challenges of these bacteria, which include group B streptococcus, E. coli, K1, and Neisseria meningitidis group B. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal anitbodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections, are included.
Claims42
A composition useful in the prophylactic or therapeutic treatment of bacterial infection due to group B streptococci, said composition comprising an in vivo protective monoclonal antibody or binding fragment thereof which binds to a group specific B carbohydrate epitope shared by serotypes of said group B streptococci.
A composition comprising a monoclonal antibody or binding fragment thereof which binds to a group specific B carbohydrate epitope shared by serotypes of group B streptococci, wherein said antibody is bactericidal against said streptococci in the presence of active complement and neutrophils.
A composition comprising a monoclonal antibody or binding fragment thereof which binds to a group specific B carbohydrate epitope shared by serotypes of group B streptococci, wherein said antibody when administered to an animal which is subsequently challenged with a lethal amount of said streptococci, prevents the death of said animal.
A composition comprising a monoclonal antibody or binding fragment thereof which binds to a group specific B carbohydrate epitope shared by serotypes of group B streptococci, wherein said antibody, when administered to an animal infected with a lethal dose of said streptococci, prevents the death of said animal.
An immortal cell line which secretes a human monoclonal antibody or binding fragment thereof which binds to an epitope of the group specific B carbohydrate shared by serotypes of group B streptococci, wherein said human monoclonal antibody is protective in vivo against infection by said group B streptococci.
The immortal cell line ATCC No. CRL 9008 or a subclone thereof.
A method for treating a patient for an infection by group B streptococci, said method comprising administering a therapeutically or prophylactically effective amount of a composition which comprises an in vivo protective monoclonal antibody or binding fragment thereof which binds to a group specific B carbohydrate epitope shared by serotypes of said group B streptococci.
Dependencies are inferred from the claim text.