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US 4,966,897 AGranted
4-substituted 17.beta.-(cyclopropyloxy)androst-5-en-3.beta.-ol and related compounds useful as C17-20 lyase inhibitors
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsMichael R. Angelastro, Thomas R. Blohm
Life of this patent
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Abstract
This invention is directed to 4-substituted 17.beta.-(cyclopropyloxy)androst-5-en-3.beta.-ols and related compounds and also to a method for using such compounds in the treatment of androgen-dependent disorders. The ethers are prepared by using the Simmons-Smith reaction and an appropriate vinyl ether.
Claims8
A compound of the formula:
- ##STR5## wherein R is hydrogen or methyl;
- Y is hydrogen or C.sub.1 -C.sub.4 alkyl;
- and Q is ##STR6## wherein Z is =O, .beta.-OH or .beta.-OZ' wherein Z' is alkanoyl of 1-10 carbon atoms or substituted C.sub.2-4 alkanoyl wherein the substituent is cyclopentane or benzene;
- Y' is hydrogen or halogen;
- and Y" is methyl or halogen.
2 more elements
A method for treating androgen-dependent disorders which comprises administering to an individual suffering from such a disorder an effective amount of a compound of the formula:
- ##STR9## wherein R is hydrogen or methyl;
- Y is hydrogen or C.sub.1 -C.sub.4 alkyl;
- and Q is ##STR10## wherein Z is =O, .beta.-OH or .beta.-OZ' wherein Z' is alkanoyl of 1-10 carbon atoms or substituted C.sub.2-4 alknaoyl wherein the substituent is cyclopentane or benzene;
- Y' is hydrogen or halogen;
- and Y" is methyl or halogen.
2 more elements
Dependencies are inferred from the claim text.