Radioiodinated phospholipid ether analogues
AssigneeUniversity of Michigan
InventorsRaymond E. Counsell, Karen L. Meyer, Susan W. Schwendner
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Abstract
Novel radioiodinated analogues of naturally occurring phospholipid ethers are tumor-specific to enable selective visualization of neoplastic lesions by gamma-camera scintigraphy. The novel compounds enable a physician to differentiate neoplastic lesions from non-neoplastic lesions in a manner not heretofore available.
Claims6
A compound of the general formula:
- ##STR12## where X is selected from the group consisting of radioactive isotopes of iodine;
- n is an integer between 1 and 15;
- Y is selected from the group consisting of H, OH, ##STR13## , and OR wherein R is an alkyl or aralkyl;
- and Z is selected from the group consisting of NH.sub.2, NR.sub.2, and NR.sub.3, wherein R is an alkyl or aralkyl.
1-[12-(m-iodophenyl)dodecyl]-2-methyl-rac-glycero-3-phosphocholine, wherein iodine is in the form of a radioactive isotope.
1-[12-(m-iodophenyl)dodecyl]-propanediol-3-phosphocholine, wherein iodine is in the form of a radioactive isotope.
Dependencies are inferred from the claim text.