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US 4,963,554 AGranted
6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
AssigneeOrtho Pharmaceutical Corporation
InventorsDonald W. Combs, Robert Falotico, David M. Ritchie
Life of this patent
Estimating the term…
Abstract
Novel 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides and their synthesis are described. These novel compounds are cardiotonic agents and bronchodilating agents, and as such are useful for the treatment of heart failure and asthma.
Claims12
A compound of the formula ##STR10## where R is phenyl, substituted phenyl or heteroaryl;
- wherein said substituted phenyl is substituted with halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, methylenedioxy, nitro, benzyloxy, amino or substituted amino, and said heteroaryl is furyl, thienyl, pyrrolo, N-substituted pyrrolo, pyridyl or substituted heteroaryl;
- wherein said substituted amino is substituted with C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 dialkyl, said N-substituted pyrrolo is substituted with C.sub.1 -C.sub.6 alkyl and said substituted heteroaryl is substituted with halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, methylenedioxy, nitro, benzyloxy, amino or substituted amino;
- wherein said substituted amino is substituted with C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 dialkyl.
Dependencies are inferred from the claim text.