Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides

A method of treating allergic reactions comprising administering to an animal in need of such treatment a therapeutically effective amount of a compound of the formula ##STR40## wherein:

• R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR41## group wherein q, r and t are independently an integer of from 1 to 8 provided that q +r +t is equal to or less than 10;
• Y is thio or sulfinyl;
• Alk is straight or branched chain lower alkylene;
• and R.sub.3 is a heterocyclic amine represented by the formula:
• ##STR42## wherein R.sub.4 is selected from the group consisting of hydrogen, lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, carboxyl or carboxyloweralkyl;
• X is selected from the group consisting of N--R.sub.4, O and --CH.sub.2 ;
• m is 2 or 3;
• n is 2 or 3 when X is 0 or N--R.sub.4, and n is I to 3 when X is CH.sub.2 ;
• p is 1 to 2;
• or the pharmaceutically acceptable salts thereof.

A method of treating proliferate skin disease comprising administering to an animal in need of such treatment a therapeutically effective amount of a compound of the formula:

• ##STR43## wherein R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR44## group wherein q, r and t are independently an integer of from 1 to 8 provided that q +r +t is equal to or less than 10;
• Y is thio or sulfinyl;
• Alk is straight or branched chain lower alkylene;
• and R.sub.3 is a heterocyclic amine represented by the formula:
• ##STR45## wherein R.sub.4 is selected from the group consisting of hydrogen, lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, carboxyl or carboxyloweralkyl;
• X is selected from the group consisting of N--R.sub.4, O and --CH.sub.2 ;
• m is 2 or 3;
• n is 2 or 3 when X is 0 or N-R.sub.4, and n is 1 to 3 when X is CH2;
• p is 0 to 2;
• or the pharmaceutically acceptable salts thereof.

A method of treating asthma comprising administering to an animal in need of such treatment a therapeutically effective amount of a compound of the formula:

• ##STR46## wherein:
• R.sub.1 and R.sub.1 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR47## group when q, r and t are independently an integer of from 1 to 8 provided that q +r +t is equal to or less that 10;
• Y is thio or sulfinyl;
• Alk is a straight or branched chain lower alkylene;
• and R.sub.3 is a heterocyclic amine represented by the formula:
• ##STR48## wherein R.sub.4 is selected from the group consisting of hydrogen, lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, carboxyl or carboxyloweralkyl;
• X is selected from the group consisting of N--R.sub.4, o and --CH.sub.2 ;
• m is 2 or 3;
• n is 2 or 3 when X is 0 or N--R.sub.4, and n is 1 to 3 when X is CH2;
• p is 0 to 2;
• or the pharmaceutically acceptable salts thereof.