# US 4,959,219 A · Coating barriers comprising ethyl cellulose

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- Number: US 4,959,219 A
- Document ID: US4959219A
- Status: Granted
- Kind: A
- Application number: 07/231,933
- Filed: 1988-08-15
- Granted: 1990-09-25
- Earliest claimed: 1988-08-15
- Assignees: Fisons Limited
- Inventors: San-Laung Chow; Yegnaswami Raghunathan
- Web page: https://patentgrep.com/patent/US4959219A

## CPC

- A61K 9/2081: {with microcapsules or coated microparticles according to A61K9/50}
- A61K 9/5015: {Organic compounds, e.g. fats, sugars}
- A61K 9/5047: {Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose}
- A61K 47/585: {Ion exchange resins, e.g. polystyrene sulfonic acid resin}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Coatings for individual ion exchange resin particles comprised of (a) ethylcellulose and (b) corn oil or acetylated monoglycerides.

## Claims

### Claim 1

An extended-release pharmaceutical composition comprised of individually coated phenylpropanolaminedivinylbenzene sulfonic acid cationic exchange resin particles, the improvement wherein the coating is comprised of (a) ethyl cellulose and (b) from about 1.6% to about 8% by weight corn oil or acetylated monoglycerides with congealing temperatures below about 23.degree. C., based upon the weight of the coated particles.

### Claim 2

In an extended release pharmaceutical composition comprised of individually coated drug-resin complex particles, the improvement wherein the coating is comprised of (a) ethylcellulose and (b) corn oil or acetylated monoglycerides with congealing temperatures below about 23.degree. C.

### Claim 3 (depends on 2)

The composition of claim 2 in tablet form.

### Claim 4 (depends on 2)

The composition of claim 2 wherein the resin of the drug-resin complex particles comprises an ion-exchange resin.

### Claim 5 (depends on 4)

The composition of claim 4 wherein component (b) of the coating comprises corn oil.

### Claim 6 (depends on 4)

The composition of claim 4 wherein component (b) of the coating comprises acetylated monoglycerides with congealing temperatures below about 23.degree. C.

### Claim 7 (depends on 5)

The composition of claim 5 wherein the ion-exchange resin comprises a divinylbenzene sulfonic acid cationic exchange resin.

### Claim 8 (depends on 6)

The composition of claim 6 wherein the ion-exchange resin comprises a divinylbenzene sulfonic acid cationic exchange resin.

### Claim 9 (depends on 5)

The composition of claim 5 wherein the coated particles comprise from about 1.6% to about 8% by weight corn oil, based on the weight of the coated particles.

### Claim 10 (depends on 6)

The composition of claim 6 wherein the coated particles comprise from about 1.6% to about 8% by weight acetylated monoglycerides with congealing temperatures below about 23.degree. C., based on the weight of the coated particles.

### Claim 11 (depends on 9)

The composition of claim 9 wherein the coated particles comprise from about 4.6% to about 6.9% by weight corn oil, based on the weight of the coated particles.

### Claim 12 (depends on 9)

The composition of claim 9 wherein the coated particles comprise from about 1.6% to about 2.4% by weight acetylated monoglycerides with congealing temperatures below about 23.degree. C., based on the weight of the coated particles.

### Claim 13 (depends on 5)

The composition of claim 5 wherein the drug comprises phenylpropanolamine.

### Claim 14 (depends on 6)

The composition of claim 6 wherein the drug comprises phenylpropanolamine.

### Claim 15 (depends on 3)

The composition of claim 3 wherein the drug is selected from the group consisting of pseudoephedrine, hydrocodone, chloropheniramine, and combinations thereof.

### Claim 16 (depends on 15)

The composition of claim 15 wherein the drug comprises pseudoephedrine.

### Claim 17 (depends on 15)

The composition of claim 15 wherein the drug comprises a mixture of hydrocodone and chlorpheniramine.

### Claim 18 (depends on 1)

The composition of claim 1 containing from about 4.6% to about 6.9% by weight corn oil, based on the weight of the coated particles.

### Claim 19 (depends on 1)

The composition of claim 1 containing from about 1.6% to about 2.4% by weight acetylated monoglycerides with congealing temperatures below about 23.degree. C., based on the weight of the coated particles.