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US 4,958,013 AGranted
Cholesteryl modified oligonucleotides
AssigneeNorthwestern University
InventorRobert L. Letsinger
Life of this patent
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Abstract
Oligonucleotides modified at their backbones by the attachment of cholesteryl are described. The modified oligonucleotides anchor in the cell membrane to serve as a probe and to provide therapeutic activity.
Claims3
An oligonucleotide comprising:
- ##STR3## wherein A is selected from the group consisting of an aliphatic alkyl, branched aliphatic alkyl, and a heteroatom containing an alkyl chain of 2 to 18 carbon atoms, R is selected from the group consisting of H and lower alkyl up to 12 carbon atoms;
- NUC is selected from the group consisting of a phosphorothioate oligonucleotide and B is a base.
Dependencies are inferred from the claim text.