Substituted cyclohexanols as central nervous system agents

A compound of Formula I ##STR58## wherein R is --OR.sup.3, wherein R.sup.3 is hydrogen, lower alkyl, phenyl lower alkyl, phenyl lower alkyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, lower alkanoyl, phenylcarbonyl, phenylcarbonyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, or phenyl lower alkanoyl, phenyl lower alkanoyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, ##STR59## wherein R.sup.4 and R.sup.5 are each independently hydrogen, lower alkyl, phenyl, phenyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, phenyl lower alkyl, phenyl lower alkyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, lower alkanoyl, phenyl lower alkanoyl, phenyl lower alkanoyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, phenylcarbonyl, phenylcarbonyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, or R.sup.4 and R.sup.5 are taken together with the nitrogen atom to which they are attached to form a ring denoted by ##STR60## wherein p is zero or an integer from 1 to 4 and R.sup.6 is hydrogen or lower alkyl, ##STR61## wherein X is oxygen or sulfur or ##STR62## wherein R.sup.6 is as defined above, or ##STR63## wherein R.sup.4 and R.sup.5 are each independently hydrogen, lower alkyl, phenyl, phenyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, phenyl lower alkyl, phenyl lower alkyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, lower alkanoyl, phenyl lower alkanoyl, phenyl lower alkanoyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, phenylcarbonyl, phenylcarbonyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, or R.sup.4 and R.sup.5 are taken together with the oxygen and nitrogen atoms to which they are attached to form a ring denoted by ##STR64## wherein q is an integer from 2 to 3 and R.sup.6 is as defined above;

• m is zero or an integer from 1 to 2;
• R.sup.1 is phenyl, phenyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or substituted by lower alkyl or halogen;
• n is zero or an integer from 1 to 4;
• R.sup.2 is ##STR65## wherein R.sup.1 is as defined above;
• and the corresponding cis and trans isomers thereof;
• or a pharmaceutically acceptable acid addition salt thereof.