Stabilization of dried bacteria extended in particulate carriers
AssigneeChr. Hansen's Laboratory, Inc.
InventorA. Louis Sudoma
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Abstract
Dried viable bacteria are admixed in a particulate carrier composed primarily of an inorganic salt of low moisture absorbing capacity together with a minor proportion of a silica gel absorbent. The inorganic salts may be sodium or calcium carbonates, bicarbonates, sulfates, or phosphates. The admixtures are storable without refrigeration.
Claims15
The method of forming a stabilized mixture of dried viable bacteria extended in a particulate carrier, comprising:
- (a) preparing a blend by intermixing a major proportion of a carrier comprising particulate inorganic salt administrable to animals with a minor proportion of a silica gel adsorbent, said carrier salt being selected to have a water adsorbing capacity of less than one percent (1%) of its moisture free weight when equilibrated in air of 50% relative humidity and being blended in at least 3 parts by weight per each part of said adsorbent, said silica gel adsorbent having a water adsorbing capacity of at least 20% of its moisture free weight when equilibrated in air at 50% relative humidity, said blend containing about 1 to 5% by weight of said adsorbent;
- (b) dispersing in said blend either during the intermixing of step (a) or subsequent thereto dried viable bacterial to form a highly diluted storable admixture thereof and
- (c) packaging said admixture in packaging material having a low vapor transmission rate.
The method of forming stabilized admixtures of dried viable harmless lactic acid producing bacteria, comprising:
- (a) preparing a blend by intermixing a particulate carrier comprising an inorganic salt administrable to animals with a silica gel adsorbent, said blend containing at least 75% by weight of said carrier salt which has a water adsorbing capacity of less than 0.3 percent of its moisture free weight when equilibrated in air of 50% relative humidity, said silica gel adsorbent being present in said blend in an amount of about 1% by weight and having a water adsorbing capacity of least 20% of its moisture free weight when equilibrated in air at 50% relative humidity;
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- (b) dispersing in said blend either during the intermixing of step (a) or subsequent thereto said dried viable lactic acid producing bacteria to form a highly diluted storable admixture thereof, said bacteria having been freeze-dried before dispersing in said blend.
The method of forming stabilized admixtures of dried viable harmless lactic acid producing bacteria, comprising:
- (a) preparing a blend by intermixing a particulate carrier with a silica gel adsorbent, said carrier being selected from calcium carbonate or sodium sulfate, said blend containing at least 75% by weight of said carrier, said adsorbent being present in said blend in an amount of about 1 to 5% by weight and having a water adsorbing capacity of at least 20% of its moisture free weight when equilibrated in air at 50% relative humidity;
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- (b) dispersing in said blend either during the intermixing of step (a) or subsequent thereto said dried viable lactic acid producing bacteria to form a highly diluted storable admixture thereof, said bacteria having been freeze-dried before dispersing in said blend.
- (c) packaging said admixture in packaging material having a low vapor transmission rate.
Dependencies are inferred from the claim text.