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US 4,956,281 AGranted
DNA sequences, recombinant DNA molecules and processes for producing lymphocyte function associated antigen-3
AssigneesBiogen, Inc., Dana-Farber Cancer Institute, Inc.
InventorsBarbara P. Wallner, Timothy A. Springer, Catherine Hession, Richard Tizard, Robert Mattaliano, Michael L. Dustin
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Abstract
Polypeptides that bind to CD2, the receptor on the surface of T-lymphocytes. Most preferably, the polypeptides bind to CD2 on the surface of T-lymphocytes and inhibit adhesion between T-lymphocytes and target cells. DNA sequences that code on expression in appropriate unicellular hosts for those polypeptides. Methods of making and using those polypeptides in therapy and diagnosis.
Claims10
A DNA sequence selected from the group consisting of:
- (a) the DNA sequence which codes for the LFA-3 polypeptide carried in phage .lambda.HT16;
- (b) DNA sequences which hybridize under conditions equivalent to about 20.degree. to 27.degree. C. below Tm and 1 M sodium chloride to the LFA-3 DNA sequence of (a) and which code on expression for a polypeptide that binds to CD2, the receptor on the surface of T-lymphocytes;
- and
- (c) DNA sequences which code on expression for a polypeptide that binds to CD2 which is coded for on expression by any of the foregoing DNA sequences.
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Dependencies are inferred from the claim text.