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US 4,954,487 AGranted
Penetrating topical pharmaceutical compositions
AssigneeThe Procter & Gamble Company
InventorsEugene R. Cooper, Maurice E. Loomans, Richard R. Wickett
Life of this patent
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Abstract
A large group of lipophilic, pharmacologically active compounds can be effectively delivered across intact skin by applying them topically in a binary, penetration-enhancing vehicle containing (1) a C.sub.3 -C.sub.4 diol, diol ester, or diol ether and (2) a cell envelope-disordering compound. This vehicle provides surprising enhancement of skin penetration for the pharmacological active, compared to either component alone.
Claims8
A composition of matter for topical administration, said composition comprising
- (a) from about 0.5% to about 35% by weight of a nonsteroidal anti-inflammatory agent selected from the group consisting of salicylic acid, ibuprofen, sulindac, naproxen, ketoprofen, ethofenamate, and indomethacin, and the pharmaceutically-acceptable salts and esters thereof;
- (b) from 0% to about 70% by weight ethanol or 2-propanol;
- and
- (c) a penetration-enhancing carrier consisting essentially of
- (i) from about 10% to about 98% by weight of the composition of propylene glycol;
- and
- (ii) from about 1% to about 5% by weight of the composition of a cell envelope-disordering compound selected from the group consisting of methyl myristate, methyl laurate, methyl caprate, ethyl myristate, ethyl laurate, ethyl caprate, myristyl acetate, lauryl acetate and capric acetate.
4 more elements
Dependencies are inferred from the claim text.