Antifungal carbinols

A compound having the formula:

• ##STR72## or a pharmaceutically or agriculturally suitable salt thereof wherein E is a bond;
• A is perfluoroalkyl of 1-8 carbon atoms, N(CH.sub.3).sub.2, OH, naphthyl optionally substituted with a total of 1-3 substituents each of which is independently selected from halogen and CF.sub.3, phenyl optionally substituted with a total of 1-3 substituents each of which is independently selected from:
• halogen, alkyl of 1-4 carbon atoms, haloalkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, and with no more than one group selected from:
• haloalkyl of 1-4 carbon atoms, CN, CO.sub.2 R.sup.14, CH.dbd.NOR.sup.14, S(O).sub.m R.sup.5, R.sup.6, 2-, 3-, or 4-pyridyl or an N-oxide thereof, imidazol-1-yl, 1,2,4-triazol-1-yl, and ##STR73## optionally substituted with 1 or 2 methyl groups;
• B is alkyl of 1-8 carbon atoms, naphthyl, biphenyl, ##STR74## perfluoroalkyl of 1-8 carbon atoms, phenyl optionally substituted with 1-3 substituents each of which is independently selected from:
• halogen, alkyl of 1-4 carbon atoms, haloalkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, and with no more than one group selected from haloalkoxy of 1-4 carbon atoms, CN, CO.sub.2 R.sup.14, CH.dbd.NOR.sup.14, S(O).sub.m R.sup.5, 2-, 3-, 4-pyridyl or an N oxide thereof.
• benzyl optionally substituted on the phenyl ring with halogen or alkyl of 1-4 carbon atoms, or optionally .alpha.-substituted with 1 or 2 methyl groups, or;
• Q is H, halogen, S(O).sub.m R.sup.11, ##STR75## CO.sub.2 R.sup.13, SCN, SSR.sup.12, or SH or its corresponding disulfide, provided however than when Q is other than H, then n is O, R, R.sup.1, and R.sup.4 are independently H or CH.sub.3, R.sub.3 is H, and A and B are each phenyl optionally substituted with from 1-3 substituents each of which is independently halogen, CH.sub.3, CF.sub.3, OCH.sub.3 or S(O).sub.m R.sup.5 ;
• L is N;
• n is 0-4 with the proviso that when A is N(CH.sub.3).sub.2, or OH, then n is other than O;
• m each occurrence is 0, 1 or 2;
• X is C, NR.sup.10, or O;
• R and R.sup.1 independently are H, alkyl of 1-4 carbon atoms, halogen, or phenyl, or taken together form cycloalkyl of 3-7 carbon atoms;
• R.sup.2 is H, allyl, propargyl, alkyl of 1-4 carbon atoms, ##STR76## or haloalkyl of 1-4 carbon atoms;
• R.sup.3 and R.sup.4 independently are H, F, or alkyl of 1-4 carbon atoms;
• R.sup.5 is alkyl of 1-4 carbon atoms;
• R.sup.6 is phenyl optionally substituted with a total of 1-3 substituents each of which is independently selected from halogen and CF.sub.3 ;
• R.sup.7 is alkyl of 1-4 carbon atoms, phenyl, or benzyl;
• R.sup.8 and R.sup.9 independently are H, alkyl of 1-4 carbon atoms, phenyl or benzyl;
• R.sup.10 is H, alkyl of 1-4 carbon atoms, or acetyl;
• R.sup.11 is alkyl of 1-4 carbon atoms, haloalkyl of 1-4 carbon atoms, CH.sub.2 CN, CH.sub.2 SCN, CH(CH.sub.3)CN, CH.sub.2 CO.sub.2 CH.sub.3, or CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 ;
• R.sup.12 is alkyl of 1-4 carbon atoms, allyl, phenyl optionally substituted with 1-2 substituents each of which is independently halogen, CH.sub.3, or OCH.sub.3, or benzyl optionally substituted with 1-2 substituents each of which is independently halogen, CH.sub.3, or OCH.sub.3 ;
• R.sup.13 is H, or alkyl of 1-4 carbon atoms;
• and
• R.sup.14 is alkyl of 1-4 carbon atoms.