Collagen wound healing matrices and process for their production
AssigneeCollagen Corporation
InventorsGeorge Ksander, Yasushi Ogawa
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Abstract
Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average pore size of 35 to 250 microns. The implants are capable of promoting connective tissue deposition, angiogenesis, reepithelialization, and fibroplasia. The wound healing matrix also serves an an effective sustained delivery system for synergistic combinations of FGF and TGF-B.
Claims10
A collagen sponge composition, comprising:
- a matrix having a density of about 0.01 to about 0.3 g/cm.sup.3, a thickness of about 1-20 mm, and having pores at least 80% of which are at least 35 um in diameter, wherein said matrix comprises
- fibrillar atelopeptide collagen, wherein said fibrils are about 50-200 nm in diameter, and are not chemically cross-linked;
- and
- a synergistic wound-healing effective amount of TGF-B and FGF.
A method for promoting wound healing in a mammal having a wound, which method comprises:
- applying to said wound a collagen sponge composition having a density of about 0.01 to about 0.3 g/cm.sup.3, a thickness of about 1-20 mm, and having pores at least 80% of which are at least 35 um in diameter, wherein said matrix comprises
- fibrillar atelopeptide collagen, wherein said fibrils are about 50-200 nm in diameter, and are not chemically cross-linked;
- and
- a synergistic wound-healing effective amount of TGF-B and FGF.
Dependencies are inferred from the claim text.