Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents

An aryl benzene oxazolidinone of the formula ##STR90## wherein, for the l, and mixtures of the d and l stereoisomers of the compound

• Ar is ##STR91## X independently is H, --NO.sub.2, --S(O).sub.n R.sub.1, --S(O).sub.2 --N.dbd.S(O).sub.p R.sub.2 R.sub.3, ##STR92## of 1 to 8 carbons optionally substituted with halogen, OH, .dbd.O other than at alpha position, S(O).sub.n R.sub.24, or NR.sub.5 R.sub.6, alkenyl of 2-5 carbons or cycloalkyl of 3-8 carbons;
• R.sub.1 is C.sub.1 -C.sub.4 alkyl, optionally substituted with halogen, OH, CN, NR.sub.5 R.sub.6 or CO.sub.2 R.sub.8 ;
• C.sub.2 -C.sub.4 alkenyl;
• --NR.sub.9 R.sub.10 ;
• --N.sub.3 ;
• ##STR93## --NG.sub.2 ;
• --NR.sub.9 G--.sup.- NGM.sup.+ ;
• R.sub.2 and R.sub.3 are independently C.sub.1 -C.sub.2 alkyl;
• R.sub.4 is alkyl of 1-4 carbons, optionally substituted with halogen;
• R.sub.5 and R.sub.6 are independently H, alkyl of 1-8 carbons, cycloalkyl of 3-8 carbons, --(CH.sub.2).sub.t OR.sub.8, --(CH.sub.2).sub.t R.sub.11 R.sub.11a, or --O(CH.sub.2).sub.t NR.sub.11 R.sub.11a;
• R.sub.7 is --NR.sub.5 R.sub.6, --OR.sub.5 or ##STR94## R.sub.8 is H or alkyl of 1-4 carbons;
• R.sub.9 is H, C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.8 cycloalkyl;
• R.sub.10 is H, C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 cycloalkyl, --OR.sub.8 or NR.sub.11 R.sub.11A ;
• R.sub.11 and R.sub.11A are independently H or C.sub.1 -C.sub.4 alkyl;
• G is Cl, Br or I;
• Y independently is H, F, Cl, Br, OR.sub.8, alkyl of 1-3 carbons, or NO.sub.2 ;
• or ##STR95## is:
• ##STR96## M is a physiologically acceptable cation;
• n is 0, 1 or 2;
• p is 0 or 1;
• r is 4 or 5;
• t is 1, 2 or 3;
• B is --NH.sub.2, ##STR97## --N--S(O).sub.u R.sub.14, or N.sub.3 ;
• R.sub.12 is H, C.sub.1 -C.sub.10 alkyl or C.sub.3 -C.sub.8 cycloalkyl;
• R.sub.13 is H;
• C.sub.1 -C.sub.4 alkyl optionally substituted with halogen, C.sub.2 -C.sub.4 alkenyl;
• C.sub.3 -C.sub.4 cycloalkyl;
• phenyl;
• --CH.sub.2 OR.sub.15 ;
• --CH(OR.sub.16)OR.sub.17 ;
• --CH.sub.2 S(O).sub.v R.sub.14 ;
• ##STR98## --OR.sub.18 ;
• --SR.sub.14 ;
• --CH.sub.2 N.sub.3 ;
• an aminoalkyl group derived from an .alpha.-amino acid selected from the group consisting of glycine, L-alanine, L-cysteine, L-proline, and D-alanine;
• --NR.sub.19 R.sub.20 ;
• or --C(CH.sub.2)R.sub.21 R.sub.22 ;
• R.sub.14 is C.sub.1 -C.sub.4 alkyl, optionally substituted with halogen;
• R.sub.15 is H or C.sub.1 -C.sub.4 alkyl, optionally substituted with halogen;
• R.sub.16 and R.sub.17 are independently C.sub.1 -C.sub.4 alkyl or, taken together are --(CH.sub.2).sub.m --;
• R.sub.18 is C.sub.1 -C.sub.4 alkyl or C.sub.7 -C.sub.11 aralkyl;
• R.sub.19 and R.sub.20 are independently H or C.sub.1 -C.sub.2 alkyl;
• R.sub.21 and R.sub.22 are independently H, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, phenyl;
• u is 1 or 2;
• v is 0, 1 or 2;
• m is 2 or 3;
• s is 2, 3, 4 or 5;
• R.sub.23 is H, alkyl of 1-8 carbons optionally substituted with halogen. cycloalkyl of 3-8 carbons, alkyl of 1-4 carbons substituted with one or more of --S(O).sub.n R.sub.24, --OR.sub.8, ##STR99## or --NR.sub.5 R.sub.6 ;
• or alkenyl of 2-5 carbons optionally substituted with CHO or CO.sub.2 R.sub.8 ;
• R.sub.24 is alkyl of 1-4 carbons or cycloalkyl of 3-8 carbons;
• and
• R.sub.25 is R.sub.6 or NR.sub.5 R.sub.6 ;
• or a pharmaceutically suitable salt thereof.