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US 4,948,723 AGranted
Method of diagnosis and severity-assessment of pancreatic disease
AssigneeBioscience International, Inc.
InventorsJohn Hermon-Taylor, Brian M. Austen
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AssigneeBioscience International, Inc.
InventorsJohn Hermon-Taylor, Brian M. Austen
Estimating the term…
Pancreatic disease can be diagnosed by assaying a patient's body fluid, e.g. serum or urine, for the activation peptides of pancreatic zymogens specifically cleaved by proteolysis during activation, (PAP) e.g. peptides including the sequence D.sub.4 K having the lysine as the carboxy terminus. When PAP is assayed for, the test provides a means for distinguishing necrotising acute pancreatitis from oedematous acute pancreatitis, provides for diagnosis of chronic pancreatitis in exacerbation, and permits monitoring of the severity progress of the disease. Also described are antibodies having specificity for the pancreatic activation peptides, as well as such peptides and antibodies which are labelled with revealing agents and/or immobilized on solid supports, and their use in diagnostic test kits.
A method of diagnosing pancreatic disease in a patient which comprises assaying a sample of the patient's body fluid for the presence or absence of peptides which are the activation peptides of pancreatic zymogens specifically cleaved by proteolysis during activation (PAP), the pancreatic zymogen being selected from the group consisting of trypsinogen, prophospholipase A.sub.2, procolipase, proelastase 1, proelastase 2, prekallekrein, procarboxypeptidases A, and procarboxypeptidases B, the activation peptide being selected from the group consisting of trypsinogen activation peptide (TAP), prophospholipase A.sub.2 activation peptide (PLAP), procolipase activation peptide (CLAP), proelastase 1 activation peptide, proelastae 2 activation peptide (PEAP), perkallekrein activation peptide, procarboxypeptidases A activation peptide and procarboxypeptidases B activation peptide,
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