Method of preparing collagen dressing sheet material
AssigneeSemex Medical, Inc.
InventorAlok Nigam
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Abstract
A mechanically stable, conformable collagen wound dressing sheet material is fabricated by lyophilizing (freeze-drying) a collagen composition and compressing the porous pad thus produced at a pressure between about 15,000-30,000 p.s.i. The sheet material thus produced may also be treated with optional dehydrothermal crosslinking known in the art. In addition to mechanical stability and conformability, the sheet material demonstrates high absorptivity, i.e., about 15-20 times its weight in isotonic saline, making it highly useful as a medical or surgical dressing or as a carrier for other medicaments such as antibiotics. The sheet material may be impregnated with thrombin.
Claims8
A method of preparing a collagen dressing sheet, including the steps of:
- (a) selecting an aqueous composition containing both soluble collagen and native collagen fibers;
- (b) charging the composition of step (a) to a mold;
- (c) lyophilizing said composition in said mold to yield a collagen mat having a thickness between 0.2-2 centimeters;
- (d) compressing said collagen mat at a pressure of between 15,000-30,000 p.s.i. to a thickness of between 0.1-0.5 centimeters;
- whereby the compressing of said mat imparts high absorptivity thereto.
Dependencies are inferred from the claim text.