Terpene amino alcohols and medicinal uses thereof
AssigneeKuraray Co., Ltd.
InventorsKoichi Kanehira, Katsushi Eziri, Manzo Shiono, Yoshiji Fujita, Johji Yamahara
Life of this patent
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Abstract
Novel terpene amino alcohols having an antiallergic activity or an activity of improving cerebral function are provided. Also provided are medicinal uses of the alcohols.
Claims5
A tarpene amino alcohol of the formula ##STR199## wherein X.sup.1 is a hydrogen atom or a hydroxyl group and Y.sup.1 is a hydrogen atom or X.sup.1 and Y.sup.1 taken together represent a bond;
- X.sup.2 is a hydrogen atom or a hydroxyl group and Y.sup.2 is a hydrogen atom or X.sup.2 nd Y.sup.2 taken together represent a bond;
- Q.sup.1 and Q.sup.2 are such that either one is Y.sup.3 with the other being ##STR200## and X.sup.3 is a hydrogen atom or a hydroxyl group;
- Y.sup.3 is a hydroxyl group when X.sup.3 is a hydrogen atom, or Y.sup.3 is a hydrogen atom or a hydroxyl group when X.sup.3 is a hydroxyl group;
- R.sup.1 and R.sup.2 taken together with the adjacent nitrogen atom form an imidazole;
- and n is an integer of 0 to 2, or a pharmaceutically acceptable ester or salt thereof.
A pharmaceutical composition for the prevention or treatment of allergic diseases or disorders of cerbral function, said composition comprising an amount, effective for the prevention or treatment of said allergic diseases or disorders of cerebral function, of a terpene amino alcohol of the formula ##STR201## wherein X.sup.1 is a hydrogen atom or a hydroxyl group and Y.sup.1 is a hydrogen atom or X.sup.1 and Y.sup.1 taken together represent a bond;
- X.sup.2 is a hydrogen atom or a hydroxyl group and Y.sup.2 is a hydrogen atom or X.sup.2 and Y.sup.2 taken together represent a bond;
- Q.sup.1 and Q.sup.2 are such that either one is Y.sup.3 with the other qroup being ##STR202## and X.sup.3 is a hydrogen atom or a hydroxyl group;
- Y.sup.3 is a hydroxyl group when X.sup.3 is a hydrogen atom, or X.sup.3 is a hydrogen atom or a hydroxyl group when X.sup.3 is a hydroxyl group;
- R.sup.1 and R.sup.2 taken together with the adjacent nitrogen atom form an imidazole and n is an integer of 0 to 2, and a pharmacologically acceptable diluent or carrier.
A method for preventing or treating allergic diseases oir disorders of cerebral function which comprises administering an effective amount for the prevention or treatment of said allergic diseases or disorders of cerebral function of a terpene amino alcohol of the formula ##STR203## wherein X.sup.1 is a hydrogen atom or a hydroxyl group and Y.sup.1 is a hydrogen atom or X.sup.1 and Y.sup.1 taken together represent a bond;
- X.sup.2 is a hydrogen atom or a hydroxyl group and Y.sup.2 is a hydrogen atom or X.sup.2 and Y.sup.2 taken together represent a bond;
- Q.sup.1 and Q.sup.2 are such that either one is Y.sup.3 with the other group being ##STR204## and X.sup.3 is a hydrogen atom or a hydroxyl atom, or Y.sup.3 is a hydrogen atom or a hydroxyl group when X.sup.3 is a hydroxyl group;
- R.sup.1 and R.sup.2 taken together with the adjacent nitrogen atom form an imidazole;
- and n is an integer of 0 to 2, or a pharmacologically acceptable ester or salt thereof.
Dependencies are inferred from the claim text.