Dietary compositions and methods using bile salt-activated lipase
AssigneeOklahoma Medical Research Foundation
InventorsJordan J. N. Tang, Chi-Sun Wang
Life of this patent
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Abstract
Dietary compositions, especially cow's milk-based infant formulas, are fortified with bile salt-activated lipase. Methods are provided for feeding newborn and premature infants which include administration of bile salt-activated lipase to increase fat digestion and therefore growth rate. Similarly, a method is provided to treat subjects for inadequate pancreatic enzyme production by administration of bile salt-activated lipase in conjunction with ingestion of fats.
Claims23
A dietary composition for a human or non-ruminant animal comprising:
- a nutritional base from a first source, the base containing fats and being poor in pile salt-activated lipase selected from the group consisting of milk bile salt-activated lipase and bile salt-activated pancreatic carboxylesterase;
- and
- an effective amount of an isolated bile salt-activated lipase derived from a second source to increase fat absorption from the first source and growth of human or non-ruminant animal.
A method for fortifying a fat-containing infant formula which is poor in bile salt-activated lipase comprising adding to the formula an effective amount of an isolated bile salt-activated lipase selected from the group consisting of milk bile salt-activated lipase and bile salt-activated pancreatic carboxylesterase to increase fat absorption from the formula and growth of the infant.
A method for treating a subject for inadequate pancreatic bile salt-activated lipase production, comprising:
- administering to the subject, in conjunction with the oral ingestion of fats, an isolated bile salt-activated lipase selected from the group consisting of milk bile salt-activated lipase and bile salt-activated pancreatic carboxylesterase in an amount sufficient to improve the digestion of the fats and increase absorption and metabolic utilization of the fats by the subject.
A method for feeding an infant a dietary base from a first source comprising fats;
- and
- administering an isolated bile salt-activated lipase selected from the group consisting of milk bile salt-activated lipase and bile salt-activated pancreatic carboxylesterase to the infant in an amount sufficient to improve the infant's digestion and absorption of the fats in the base and increase the growth of the infant, wherein the lipase is derived from a second source.
A composition for improving the absorption and metabolic utilization of ingested fats comprising:
- an isolated bile salt-activated lipase selected from the group consisting of milk bile salt-activated lipase and bile salt-activated pancreatic carboxylesterase in a vehicle suitable for oral ingestion, wherein said lipase is present in a dosage providing at least 1 mg lipase/2000 mg ingested fat.
Dependencies are inferred from the claim text.