Prolonged activity nicotine patch
AssigneePharmetrix Corporation
InventorsRichard W. Baker, Frank Kochinke, Carl Huang
Life of this patent
Estimating the term…
Abstract
A transdermal patch for delivering nicotine for prolonged periods of 12-24 hours. The patch includes a rate-controlling membrane or monolith to keep the nicotine flux within useful and safe limits. The patch is typically replaced once a day, and can be used for smoking cessation therapy or in other situations where systemic nicotine delivery is indicated.
Claims22
A transdermal patch, comprising:
- (a) A nicotine depot layer, having a skin-facing side and a skin-distal side, said depot layer containing a sufficient quantity of nicotine to maintain a useful flux of nicotine from said patch for a total time period of 12 hours or more;
- (b) an occlusive backing layer in contact with and covering said depot layer on said skin-distal side;
- and
- (c) rate-controlling means for controlling diffusion of nicotine from said skin-facing side at a first flux of greater than zero but less than 2 mg/cm.sup.2 in any hour for a first time period of greater than zero but less than 5 hours, then at a second flux between 20 and 800 .mu.g/cm.sup.2.h for a second time period of 7 hours or more.
A transdermal patch, comprising:
- (a) a nicotine depot layer, having a skin-facing side and a skin-distal side, said depot layer containing a sufficient quantity of nicotine to maintain a useful flux of nicotine from said patch for a period of 12 hours or more;
- (b) an occlusive backing layer in contact with and covering said depot layer on said skin-distal side;
- and
- (c) rate-controlling means for controlling diffusion of nicotine from said skin-facing side at a flux between 20 and 800 .mu.g/cm.sup.2.h for a period of 12 hours or more.
A method of administering nicotine to an individual in need of such administration, comprising applying to the skin of said individual a transdermal patch, said patch comprising:
- (a) a nicotine depot layer, having a skin-facing side and a skin-distal side, said depot layer containing a sufficient quantity of nicotine to maintain a useful flux of nicotine from said patch for a total time period of 12 hours or more;
- (b) an occlusive backing layer in contact with and covering said depot layer on said skin-distal side;
- and
- (c) rate-controlling means for controlling diffusion of nicotine from said skin-facing side at a first flux less 2 mg/cm.sup.2.h for a first time period less than 5 hours, then at a second flux between 20 and 800 .mu.g/cm.sup.2.h for a second time period of 7 hours or more.
A method of administering nicotine to an individual in need of such administration, comprising applying to the skin of said individual a transdermal patch, said patch comprising:
- (a) a nicotine depot layer, having a skin-facing side and a skin-distal side, said depot layer containing a sufficient quantity of nicotine to maintain a useful flux of nicotine from said patch for a period of 12 hours or more;
- (b) an occlusive backing layer in contact with and covering said depot layer on said skin-distal side;
- and
- (c) rate-controlling means for controlling diffusion of nicotine from said skin-facing side at a flux between 20 and 800 .mu.g/cm.sup.2.h for a period of 12 hours or more.
Dependencies are inferred from the claim text.