Water soluble, antineoplastic derivatives of taxol

Antineoplastic water soluble derivatives of taxol having the following formula:

• ##STR4## wherein:
• Z=ethylene, propylene, CHCH, 1,2-cyclohexane, 1,2-phenylene,
• R.sup.1 =OH base, NR.sup.2 R.sup.3, OR.sup.3, SR.sup.3, OCH.sub.2 CONR.sup.4 R.sup.5, OH
• R.sup.2 =hydrogen, methyl
• R.sup.3 =(CH.sub.2).sub.n NR.sup.6 R.sup.7 ;
• (CH.sub.2).sub.n NR.sup..sym.6 R.sup.7 R.sup.8 X.sup..crclbar.
• n=1 to 3
• R.sup.4 =hydrogen, lower alkyl containing 1 to 4 carbons
• R.sup.5 =hydrogen, lower alkyl containing 1 to 4 carbons, benzyl, hydroxyethyl, CH.sub.2 CO.sub.2 H, dimethylaminoethyl
• R.sup.6 R.sup.7 =lower alkyl containing 1 or 2 carbons, benzyl or R.sup.6 and R.sup.7 together with the nitrogen atom of NR.sup.6 R.sup.7 form the following rings ##STR5## R.sup.8 =lower alkyl containing 1 or 2 carbons, benzyl X.sup..crclbar. =halide
• base=NH.sub.3, (HOC.sub.2 H.sub.4).sub.3 N, N(CH.sub.3).sub.3, CH.sub.3 N(C.sub.2 H.sub.4 OH).sub.2, NH.sub.2 (CH.sub.2).sub.6 NH.sub.2, N-methylglucamine, NaOH, KOH.