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US 4,939,137 AGranted
Ring-fused thienopyrimidinedione derivatives
AssigneeOrtho Pharmaceutical Corporation
InventorsRonald K. Russell, Richard A. Rampulla
Life of this patent
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Abstract
The synthesis of ring-fused thienopyrimidinedione derivatives is described. The novel ring-fused thienopyrimidinedione derivatives are generally vasodilating agents and antihypertensive agents and as such are useful as cardiovascular agents.
Claims18
A compound of the formula ##STR8## where X is C.dbd.O or CHOR.sub.3 or C.dbd.NOR.sub.4 or CHNHR.sub.3 when Y is CH.sub.2 or X and Y together are CH.dbd.CH or Y is NH when
- X is C.dbd.O ##STR9## R.sub.1 is hydrogen, halogen, nitro or C.sub.1 -C.sub.3 alkyl R.sub.2 is ##STR10## R.sub.3 is hydrogen, C.sub.1 -C.sub.3 alkyl or COR.sub.5 ;
- R.sub.4 is hydrogen or C.sub.1 -C.sub.6 alkyl;
- R.sub.5 is C.sub.1 -C.sub.6 alkyl, phenyl or phenyl substituted by halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.3 alkoxy, nitro, CF.sub.3, amino or C.sub.1 -C.sub.6 dialkylamino;
- Ar is phenyl or phenyl substituted by halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.3 alkoxy, nitro, CF.sub.3, amino or C.sub.1 -C.sub.6 dialkylamino;
- m is 1-5;
- and
- n is 2-6
4 more elements
Dependencies are inferred from the claim text.