Certain cycloalkane-1,1-diphosphonic acids and derivatives thereof having the ability to treat diseases associated with abnormal calcium and phosphate metabolism
AssigneeThe Procter & Gamble Company
InventorsJames J. Benedict, Karen Y. Johnson
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Abstract
Novel cyclic geminal-diphosphonic acid compounds, and pharmaceutical compositions containing these compounds, which are useful for treating diseases characterized by abnormal calcium and phosphate metabolism; and a method of treating diseases characterized by abnormal calcium and phosphate metabolism utilizing these novel cyclic diphosphonic acid compounds.
Claims24
A cyclic diphosphonic acid, or a pharmaceutically-acceptable salt thereof, having the structure:
- ##STR9## wherein R.sub.1 is selected from the group consisting of alkyl having from 1 to 6 carbon atoms, substituted alkyl having from 1 to 6 carbon atoms, phenyl, substituted phenyl, naphthyl, substituted naphthyl, benzyl, substituted benzyl, hydroxy, halogen, amino, substituted amino, acyl amino having from 1 to 6 carbon atoms, carboxy, carbonyl, and alkoxy;
- and said substituted R.sub.1 groups are substituted with a member selected from the group consisting of methyl, amino, C.sub.1 -C.sub.6 alkylamino, chloro, hydroxy and methoxy.
3-Chlorocyclopentane-1,1-diphosphonic acid, or a pharmaceutically-acceptable salt thereof.
Cyclohexane-1,1-diphosphonic acid, or a pharmaceutically-acceptable salt thereof.
Cyclohex-2-ene-1,1-diphosphonic acid, or a pharmaceutically-acceptable salt thereof.
Cyclohex-3-ene-1,1-diphosphonic acid, or a pharmaceutically-acceptable salt thereof.
Cycloheptane-1,1-diphosphonic acid, or a pharmaceutically-acceptable salt thereof.
1-Methylcyclobutane-1,1-diphosphonic acid, or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.