Fecal occult blood test methods
AssigneeLitmus Concepts, Inc.
InventorPaul J. Lawrence
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Abstract
An improved method for detecting peroxidatively active materials in a sample is provided, the method incorporating antimalarial drugs such as quinine, quinidine, chloroquine, primaquine, and quinacrine as modulating compounds. In a preferred embodiment, the method is a fecal occult blood test (FOBT), in which a fecal specimen is contacted with a chromogen and a hydroperoxide in the presence of a selected quinoline derivative. The method enables careful modulation of test sensitivity and specificity, and further provides an FOBT in which interference from dietary meat ingestion is substantially eliminated.
Claims29
In an improved method for detecting the presence of a peroxidatively active substance in a sample by contacting the sample with a chromogen and a hydroperoxide, the improvement comprising applying to the sample, along with the chromogen and the hydroperoxide, a modulating compound which is an accelerator selected from the group consisting of chloroquine, quinacrine, and mixtures thereof.
In an improved method for detecting the presence of a peroxidatively active substance in a sample by contacting the sample with a chromogen and a hydroperoxide, the improvement comprising applying to the sample, along with the chromogen and the hydroperoxide, an accelerator selected from the group consisting of chloroquine, quinacrine and mixtures thereof, and an inhibitor selected from the group consisting of quinine, primaquine, quinidine and mixtures thereof.
Dependencies are inferred from the claim text.