Fecal occult blood test method
AssigneeLitmus Concepts, Inc.
InventorPaul J. Lawrence
Life of this patent
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Abstract
Fecal occult blood tests of enhanced sensitivity, specificity, and readability are provided by employing (1) a developer or complete reagent solution that uses as a solvent system a solvent comprising at least about 50% by volume of a solvent for iron protoporphyrins such as dimethyl sulfoxide and/or (2) a multi-chromagen comprised of a mixture of guaiac and ABTS. Test results may be further improved by incorporating hemoprotein solubilizing agents, plant peroxidase inhibitors, iron/copper chelating agents, accelerators and buffers in the developer/reagent.
Claims5
In a fecal occult blood test method comprising contacting a fecal specimen on a solid test matrix with a leuco dye and a hydroperoxide the improvement wherein the hydroperoxide or the hydroperoxide and the leuco dye are applied to the specimen in solution in a solvent comprising at least 50% by volume of a solvent for iron protoporphyrins whereby iron protoporphyrins in the specimen are dissolved.
Dependencies are inferred from the claim text.