Stabilization of compounds
AssigneeRadiometer Corporate Development Ltd.
InventorMichael H. Coleman
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Abstract
A process for stabilizing compounds which comprises dispensing a solution of a film-forming material and the compound to be stabilized on a solid surface and allowing the solvent to evaporate to leave on the solid surface a quantity of material in the form of a thin coherent, dry flim adhering to said solid surface; and device for the application of said method and especially useful for performing biological tests.
Claims23
An improved device for carrying out a biological test, said device comprising a plate having a plurality of wells therein and a mechanically and chemically stabilized biologically active test compound located in said wells, said compound being located in said wells in a dry form compatible with requirements for the culture of microorganisms and constituting a part of a coherent dry film having a thickness of 0.01 to 5 microns, said film being adherent to the inner surface of its respective well and said film including a water-soluble polymeric film-forming substance in addition to said biologically active compound so that said compound is held in said wells in mechanically and chemically stabilized form.
In a method for the testing of microorganisms in a liquid medium, the improvement which comprises dispensing a bacterial culture broth containing microorganisms into at least one well of a plate having a plurality of wells therein and a mechanically and chemically stabilized biologically active test compound located in said wells, said compound being located in said wells in a dry form compatible with requirements for the culture of microorganisms and constituting a part of a coherent dry film having a thickness of 0.01 to 5 microns, said film being adherent to the inner surface of the respective wells and said film including a water soluble polymeric film-forming substance in addition to said biologically active compound so that the compound is held in said wells in a mechanically and chemically stabilized form, and the plate is incubated.
Dependencies are inferred from the claim text.