Covalently linked polypeptide cell modulators
AssigneeG. D. Searle & Co.
InventorsLeslie D. Bell, Keith G. McCullagh, Alan G. Porter
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Abstract
Described is a new class of polypeptide cell modulators characterized by being composed of two covalently linked cell modulators in a linear polypeptide sequence. Such dual function polypeptides have new and particularly useful activities when the component polypeptide cell modulators are interferons, lymphokines or cytotoxins which act through different and specific cell receptors to initiate complementary biological activities.
Claims14
A composition represented by the formula
- R.sub.1 --L--R.sub.2
- wherein R.sub.1 is gamma interferon or a biologically active modified gamma interferon;
- R.sub.2 is beta interferon or a biologically active modified beta interferon;
- and L is a peptide linker segment of 1 to 500 amino acid residues.
The protein identified in FIG. 8 and FIG. 9 as IFNX 601 and having the amino acid sequence shown in FIG. 8 and FIG. 9.
The protein identified in FIG. 10 and FIG. 11 as IFNX 602 and having the amino acid sequence shown in FIG. 10 and FIG. 11.
Dependencies are inferred from the claim text.