.beta.-lactam compounds
AssigneeSumitomo Pharmaceuticals Company, Limited
InventorsMakoto Sunagawa, Haruki Matsumura, Takaaki Inoue, Masatomo Fukasawa, Masuhiro Kato
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Abstract
Novel .beta.-lactam compounds belonging to carbapenem or penem derivatives useful as antimicrobial agents or intermediates therefor and a process for producing these compounds are disclosed.
Claims13
A .beta.-lactam compound represented by the formula:
- ##STR386## wherein R.sub.1 represents a hydrogen atom, a 1-hydroxyethyl group or a 1-hydroxyethyl group in which the hydroxy group is protected with a protecting group for a hydroxy group;
- R.sub.2 represents a hydrogen atom or a protecting group for an amino group;
- R.sub.3 represents a hydrogen atom or a protecting group for a carboxyl group;
- X represents a sulfur atom;
- and Y represents a group of the formula (2):
- ##STR387## wherein R.sub.5 and R.sub.6, which may be the same or different, each represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an aralkyl group having 1 to 2 carbon atoms in the alkyl moiety thereof, a substituted alkyl group having 1 to 4 carbon atoms wherein said substituent is selected from the group consisting of hydroxyl, di-(C.sub.1 -C.sub.3)-alkylamino, carbamoyl, or R.sub.5 and R.sub.6 are taken together to represent an alkylene chain to form, together with the adjacent nitrogen atom, a 4- to 7-membered cyclic amino group.
(5R)-3-[2-((1-Pyrrolidino)carbonyl)pyrr olidin-4-ylthio-6-(1-hydroxyethyl)-1-azabicyclo[3,2,0]hept-2-ene-7-one-4-th ia-2-carboxylic acid, or a non-toxic pharmaceutically acceptable salt thereof.
(5R)-3 -[2-Carbamoylpyrrolidin-4-ylthio]-6-(1-hydroxyethyl)-1-azabicyclo[3,2,0]hep t-2-ene-7-one-4-thia-2-carboxylic acid, or a non-toxic pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.