Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor
AssigneeSalutar, Inc.
InventorsSteven C. Quay, Scott M. Rocklage, Warren K. Miller
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Abstract
The presence and location of amyloid deposits in an organ or body area of a patient is effected by intravenous administration of novel radioactive iodine-labeled amyloid binding compounds and preferably .sup.123 I-labeled compounds to the patient and sensing radiation emitted from the organ or body area. Novel non-radioactive iodine substituted amyloid binding compounds and amyloid binding compounds which are readily iodinated are further aspects of the invention.
Claims7
An amyloid binding diazo compound of Formula I, Formula II, Formula III or Formula IV or a water-soluble, non-toxic salt thereof:
- ##STR13## wherein I* is a non-radioactive or radioactive iodine moiety;
- R.sub.1 is amino or hydroxy;
- R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydrogen or sulfo, with the proviso that not more than two of R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are sulfo and sulfo is not present on adjacent carbons;
- R.sub.8, R.sub.9 and R.sub.10 are hydrogen, hydroxy, carboxy or lower alkyl esters thereof, methyl, or methoxy;
- R.sub.12 and R.sub.14 are each independently hydrogen, methyl, chloro, methoxy, carboxy or a lower alkyl ester thereof, sulfo or nitro;
- and
- R.sub.13 and R.sub.15 are each independently hydrogen or sulfo;
- ##STR14## wherein R.sub.20, R.sub.24, R.sub.25 and R.sub.29 each independently are hydrogen, hydroxy or amino, with the proviso that R.sub.24 is not the same as R.sub.20 and R.sub.29 is not the same as R.sub.25 ;
- R.sub.21, R.sub.22, R.sub.23, R.sub.26, R.sub.27 and R.sub.28 each independently are hydrogen or sulfo, with the proviso that not more than two of R.sub.21, R.sub.22 and R.sub.23 is sulfo and not more than two of R.sub.26, R.sub.27 and R.sub.28 is sulfo, and sulfo is not present on adjacent carbons;
- R.sub.30 and R.sub.32 are each independently hydrogen, methyl, chloro, methoxy, carboxy or a lower alkyl ester thereof, sulfo or nitro;
- R.sub.31 and R.sub.33 are each independently hydrogen or sulfo;
- X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are each independently hydrogen or I*, with the proviso that X.sub.1 is hydrogen when R.sub.21 is sulfo, X.sub.2 is hydrogen when R.sub.22 and R.sub.23 is sulfo, X.sub.3 is hydrogen when R.sub.26 is sulfo, and X.sub.4 is hydrogen when R.sub.27 or R.sub.28 is sulfo;
- ##STR15## wherein R.sub.40 and R.sub.41 are hydroxy or amino, and R.sub.40 and R.sub.41 are not the same group;
- R.sub.42, R.sub.43, R.sub.44, R.sub.45, and R.sub.46 are hydrogen or sulfo;
- one or two of R.sub.42, R.sub.43, R.sub.44, R.sub.45, and R.sub.46 are sulfo;
- and sulfo is not present on adjacent carbons;
- and
- R.sub.47 is hydrogen, methyl or carboxy;
- or ##STR16## wherein R.sub.50 is hydrogen or sulfo;
- R.sub.51 is methyl or carboxy;
- and
- R.sub.52, R.sub.53 and R.sub.54 each are hyrogen, hydroxy, carboxy or lower alkyl esters thereof, methyl, or methoxy.
As a compound of claim 2,
- 4-amino-3-(4-(1-carboxy-2-hydroxy-3-.sup.123 I-5-phenyldiazo)-biphen-4'-yldiazo)-naphthalene-1-sulfonic acid, or a water-soluble, non-toxic salt thereof.
Dependencies are inferred from the claim text.