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US 4,929,623 AGranted
Benzothiazole derivative
AssigneeEisai Co., Ltd.
InventorsShinya Abe, Mitsuaki Miyamoto, Masayuki Tanaka, Kozo Akasaka, Kenji Hayashi, Tetsuya Kawahara, Satoshi Katayama, Yoshinori Sakuma, Takeshi Suzuki, Isao Yamatsu
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Abstract
A benzothiazol compound having the formula is disclosed and is effective to inhibit the production of leukotriene. It is useful against allergy, asthma, affections of the skin, allergic rhinitis and affection of a cardiovascular system. ##STR1## in which R20 is ester or amide and --NR5R6 is amino in variety.
Claims27
A benzothiazole compound having the formula:
- ##STR214## wherein R.sup.1, R.sup.3, and R.sup.4 may be the same or different and are each a hydrogen atom, a lower alkyl group, a halogen atom, an acyl group, a hydroxyl group, a lower alkoxy group, a hydroxy lower alkyl group, a nitro group, an amino group, or a lower dialkylamino group, provided that any two of R.sup.1, R.sup.3 and R.sup.4 may be combined together to form an aromatic ring which may consist of only carbon atoms or additionally contain a nitrogen atom,
- R.sup.2 is a hydrogen atom, an acyl group, a group represented by the formula:
- ##STR215## wherein R.sup.7 and R.sup.8 may be the same or different and are each a hydrogen atom or a lower alkyl group,
- R.sup.5 is a hydrogen atom, and
- R.sup.6 is a group represented by the formula:
- ##STR216## wherein X is a --CO-- or a --CH.sub.2 --, and Y is a lower alkyl group or a group represented by the formula:
- ##STR217## wherein R.sup.9 and R.sup.10 may be the same or different and are each a hydrogen atom, a lower alkyl group, a halogen atom, a lower alkoxy group, a hydroxy lower alkyl group or a lower dialkyl group or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.